|
GENTAUR
Tel: +32 16 58 90 45
Fax: + 32 16 50 90 45
info@genprice.com
Av. de l'Armée 68
• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
Tel: 01 43 25 01 50
9, Rue Lagrange
• 75005 PARIS • FRANCE
| |
B-7204 Bisindolylmaleimide X, Hydrochloride Salt,
>99%
[Ro 31-8425] [2-(8-Aminomethyl-6,7,8,9-tetrahydropyrido[1,2-
a]indol-3-yl)-3-(1-methylindol-3-yl)maleimide, HCl Salt] [3-(8-Aminomethyl-6,7,8,9-tetrahydropyrido[1,2
-a]indol-10-yl)-4-(1-methylindol-3-yl)-1H -pyrrole-2,5-dione,
HCl Salt]
| M.W. 460.96 |
C26H24N4O2•HCl
|
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Disposal: A
 | Potent inhibitor of PKC; IC50 = 15 nM against rat
brain PKC. IC50's for the inhibition of the group A
PKCs range from 8-13 nM and that for PKCε = 39 nM. Wilkenson, S.E. et
al. Biochem. J. 294: 335-337 (1993). (Please request
Technical Note #2 for additional information on PKC nomenclature.) |
| Other kinases are inhibited at much higher concentrations, e.g., PKA (IC50
= 2.8 µM), phosphorylase kinase (IC50 = 1.3 µM) and
myosin light chain kinase (IC50 = 3.7 µM). Bit, R.A.
et al. J. Med. Chem. 36: 21-29 (1993). |
| See the product description for Bisindolylmaleimide I, Cat. No.
B-2464, for a cautionary note regarding the effects of ATP concentrations on
apparent inhibitory potencies. |
|
