B7334

GENTAUR

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Av. de l'Armée 68 • B-1040 BRUSSELS • BELGIUM

GENTAUR FRANCE

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9, Rue Lagrange • 75005 PARIS • FRANCE

B-7334 Bisindolylmaleimide IX, Methanesulfonate Salt, >99%

[Ro 31-8220] [2-{1-[3-(Amidinothio)propyl]-1H-indol-3 -yl}-3-(1-methylindol-3-yl)maleimide, Methanesulfonate Salt] [3-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-4-(1 -methylindol-3-yl)-1H-pyrrole-2,5-dione, Methanesulfonate Salt]

M.W. 553.66 C₂₅H₂₃N₅O₂ S•CH₄O₃S [138489-18-6]

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A

·         Selective PKC inhibitor (IC50 = 10 nM). IC50 for the inhibition of PKA is 900 nM. Davis, P.D. et al. J. Med. Chem. 35: 994-1001 (1992).

·         IC50's for the inhibition of the group A PKCs range from 5-27 nM and that for PKCε = 24 nM. Wilkenson, S.E. et al. Biochem. J. 294: 335-337 (1993). (Please request Technical Note #2 for additional information on PKC nomenclature.)

·         See the product description for Bisindolylmaleimide I, Cat. No. B-2464, for a cautionary note regarding the effects of ATP concentrations on apparent inhibitory potencies.

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