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B-7457 Bisindolylmaleimide VIII, Acetate Salt,
>99%
[Ro 31-7549] [2-[1-(3-Aminopropyl)indol-3-yl]-3-(1-methylindol-3-yl)maleimide,
Acetate Salt] [3-[1-(3-Aminopropyl)indol-3-yl]-4-(1-methylindol-3-yl)-1
H-pyrrole-2,5-dione, Acetate Salt]
| M.W. 458.52 |
C24H22N4
O2•C2H4O2 |
[138516-31-1] |
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Disposal: A
 | Selective PKC inhibitor (IC50 = 75 nM). IC50
for the inhibition of PKA is 5.2 µM. Davis, P.D. et al. J. Med.
Chem. 35: 994-1001 (1992). Nixon, J.S. et al. Biochem.
Soc. Trans. 20: 419-425 (1992). |
| IC50's for the inhibition of the group A PKCs
range from 53-213 nM and that for PKCε = 175 nM. Wilkenson, S.E. et al.
Biochem. J. 294: 335-337 (1993). (Please request Technical
Note #2 for additional information on PKC nomenclature.) |
| See the product description for Bisindolylmaleimide I, Cat. No.
B-2464, for a cautionary note regarding the effects of ATP concentrations on
apparent inhibitory potencies. |
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