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B-8500 Brefeldin A, >99%
[Decumbin] [Ascotoxin] [Cyanein]
[BFA]
| M.W. 280.40 |
C16H24 O4
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M.I. 11: 1363 |
[20350-15-6]
RTECS: GY8410000 |
Warning: Toxic.
Storage: Store at or below -20 ºC in the dark.
Solubility: Soluble in DMSO or ethanol. Disposal: A
 | Specifically and reversibly blocks translocation of proteins from the
endoplasmic reticulum to the Golgi apparatus. Misumi, Y., et. al.
"Novel blockade by brefeldin A of intracellular transport of secretory
proteins in cultured rat hepatocytes." J. Biol. Chem. 261:
11398-11403 (1986). |
| Brefeldin A has been shown to induce apoptosis in human tumor cells via
a process requiring caspase activation. Guo, H., et. al. "Brefeldin
A-mediated apoptosis requires the activation of caspases and is inhibited by
Bcl-2." Exp. Cell Res. 245: 57-68 (1998). |
| Brefeldin A has been identified as an activator of the sphingomyelin
signal transduction cycle. Linardic, C. M., et. al. "Activation of
the sphingomyelin cycle by brefeldin A: effects of brefeldin A on
differentiation and implications for a role for ceramide in regulation of
protein trafficking." Cell Growth Differ. 7: 765-774 (1996).
Alessenko A. V. "The role of sphingomyelin cycle metabolites in transduction
of signals of cell proliferation, differentiation and death." Membr. Cell
Biol. 13: 303-320(2000). |
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