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C-3800 (S)-(+)-Camptothecin, >99%
[CPT] [NSC-100880]
| M.W. 348.36 |
C20H16N2O4 |
[7689-03-4]
RTECS UQ0492000 |
M.I. 13: 1743 |
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO, up to about 10 mg/ml. Disposal: A
 | Camptothecin induces strand breaks in chromosomal DNA and inhibits
mammalian DNA topoisomerase I catalytic activity. Hsiang, Y.H., et al.
"Camptothecin induces protein-linked DNA breaks via mammalian DNA
topoisomerase I." J Biol Chem. 260: 14873-14878 (1985). |
| A potent antitumor antibiotic, camptothecin inhibits human breast
carcinoma cell growth in vitro and induces complete regression of
human breast tumors grown in nude mice. Pantazis. P., et al.
"Efficacy of camptothecin congeners in the treatment of human breast
carcinoma xenografts." Oncol Res. 5: 273-281 (1993).
Thomas, C.J., et al. "Camptothecin: current perspectives."
Bioorg Med Chem. 12: 1585-1604 (2004). |
| Inhibits (IC50 = 30 nM) Tat protein-mediated
transactivation of HIV-1 viral long terminal repeat (LTR). Li, C.J., et
al. "Camptothecin inhibits Tat-mediated transactivation of type 1 human
immunodeficiency virus." J Biol Chem. 269: 7051-7054 (1994). |
| Enhances PKCα activity during apoptosis in HL60 myeloid leukemia cells
via a caspase-regulated hyperphosphorylation mechanisn. Shao, R.G., et
al. "Activation of PKCalpha downstream from caspases during apoptosis
induced by 7-hydroxystaurosporine or the topoisomerase inhibitors,
camptothecin and etoposide, in human myeloid leukemia HL60 cells." J
Biol Chem. 272: 31321-31325 (1997). |
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