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GENTAUR
Tel: +32 16 58 90 45
Fax: + 32 16 50 90 45
info@genprice.com
Av. de l'Armée 68
• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
Tel: 01 43 25 01 50
9, Rue Lagrange
• 75005 PARIS • FRANCE
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C-6000 Cyclosporin A, >99%
[Cyclosporine] [Antibiotic S 7481F1] [Ciclosporin
A] [Ramihyphin A] [CsA]
| M.W. 1202.64 |
C62H111N11O12 |
[59865-13-3]
RTECS GZ4120000 |
M.I. 12: 2821 |
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO or ethanol; (1 mL of ethanol will dissolve 160 mg).
Disposal: A
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Cyclic hydrophobic oligopeptide isolated from
the filamentous fungi, Tolypocladium inflatum, with potent
immunosuppressant properties. Induces apoptosis in rat thymocytes and in
murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines
induced by anti-IgM and ionomycin. Donjerkovic, D. et al.
"Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of
c-Myc and calcium." Cell. Growth Differ. 10: 695-704 (1999).
Mordvinov, V.A. et al. "A human T-cell line with inducible production
of interleukins 5 and 4. A model for studies of gene expression." J.
Immunol. Methods 228: 163-168 (1999). Zaidan, E. et al.
"Cyclosporin A-sensitive changes in mitochondrial glutathione are an early
response to intrastiatal NMDA or forebrain ischemia in rats." J.
Neurochem. 73: 2214-2217 (1999). Gottschalk, A.R., et al.
"Identification of immunosuppressant-induced apoptosis in a murine B-cell
line and its prevention by bcl-x but not bcl-2." Proc. Natl. Acad. Sci.
USA 91: 7350-7354 (1994). |
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The complex of cyclosporin A with the protein
cyclophilin inhibits T-cell receptor signal transduction pathway via the
inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity
(Ki = 270 nM). Etzkorn, F.A., Chang, Z.Y., Stolz,
L.A., Walsh, C.T. Cyclophilin residues that affect noncompetitive inhibition
of the protein serine phosphatase activity of calcineurin by the
cyclophilin-cyclosporin A complex." Biochemistry 33: 2380-2388
(1994). Liu, J. "FK506 and ciclosporin: molecular probes for studying
intracellular signal transduction." Trends Pharmacol. Sci. 14:
182-188 (1993). |
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Inhibits interleukin-1α-, lipopolysaccharide-,
and TNF-α-nitric oxide synthesis induction. Fast, D.J., et al.
"Cyclosporin A inhibits nitric oxide production by L929 cells in response to
tumor necrosis factor and interferon-gamma." J. Interferon Res. 13:
235-240 (1993). Marumo, T., et al. "Cyclosporin A inhibits nitric
oxide synthase induction in vascular smooth muscle cells." Hypertension
25: 764-768 (1995). Hattori, Y., and Naranishi, N. "Effects of
cyclosporin A and FK506 on nitric oxide and tetrahydrobiopterin synthesis in
bacterial lipopolysaccharide-treated J774 macrophages." Cell Immunol.
165: 7-11 (1995). |
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See also our other standard immunosuppressant
products:
| F-4900 FK-506 |
| R-5000 Rapamycin |
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