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GENTAUR
Tel: +32 16 58 90 45
Fax: + 32 16 50 90 45
info@genprice.com
Av. de l'Armée 68
• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
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9, Rue Lagrange
• 75005 PARIS • FRANCE
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D-9200 (R,S)-2,3-Dihydrodaidzein, >99%
This compound is currently out of stock and is anticipated
to be
ready for shipment on the following date: indefinite.
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO, methanol, or ethanol. Disposal: A
 | Human urinary metabolite of daidzein. Heinonen, S. et al.,
"Identification of isoflavone metabolites dihydrodaidzein, dihydrogenistein,
6'-OH-O-dma, and cis-4-OH-equol in human urine by gas
chromatography-mass spectrometry using authentic reference compounds." Anal.
Biochem. 274: 211-219 (1999). |
| This product is a racemic mixture of the R- and S-enantiomers.
As of this writing, we are not aware of any studies establishing the
stereochemistry of the human urinary metabolite form of dihydrodaidzein.
This is an important point; the natural metabolite is likely to be a single
stereoisomer with different biological properties from the racemic mixture. |
| The Heinonen et al. article makes many references to the "enol
tautomer" of dihydrodaidzein. Although is it not always obvious from the
wording in their descriptions, a careful reading indicates that all
references in this article to the "enol tautomer" of dihydrodaidzein refer
to a silylated derivative of this compound. The trimethylsilyl ether
of the enol is indeed an isolatable compound, whereas the free, unsilylated
enol form is in dynamic equilibrium with the keto form and cannot be
isolated separately. |
| We have found that dihydrodaidzein is somewhat unstable in air; it
partially oxidizes to form daidzein if left at room temperature for a few
days, even if kept in the dark as a dry powder. Storage in solid form at
-20 ºC under nitrogen is recommended. Solutions are expected to be even
more susceptible to oxidation than the solid, so they should be freshly
prepared and used as quickly as possible. NOTE: Although there are
one or two exceptions, we generally do not carry products that are unstable
and not easily maintained at 98-99+% purity under ordinary handling
conditions. At present, dihydrodaidzein is not in stock, and we are working
to solve production problems for this compound related to its stability. |
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