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GENTAUR
Tel: +32 16 58 90 45
Fax: + 32 16 50 90 45
info@genprice.com
Av. de l'Armée 68
• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
Tel: 01 43 25 01 50
9, Rue Lagrange
• 75005 PARIS • FRANCE
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G-6203 Gö 6976, >99%
[12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]
carbazole]
This compound is currently out of stock and is anticipated
to be
ready for shipment on the following date: indefinite.
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Appearance: Off-white to yellow solid.
Disposal: A
 | Novel, very potent PKC inhibitor with high selectivity for the A-group
of PKC isotypes (α, β, and γ), with IC50 values in
the 2-10 nM range. Little or no inhibition of the B- and C-groups of PKC
isotypes, even at much higher concentrations. Kleinschroth, J.,
Hartenstein, J., Rudolph, C. and Schächtele, C.
"Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of
protein kinase C." Bioorg. Med. Chem. Lett. 3: 1959-1964
(1993). Martiny-Baron, G., Kazanietz, M.G., Mischak, H., Blumberg, P.,
Kochs, G., Hug, H., Marme, D. and Schächtele, C. "Selective inhibition of
protein kinase C isozymes by the indolocarbazole Gö 6976. " J. Biol.
Chem. 268: 9194-9197 (1993). |
| Please request Technical Note #2 for additional information about the
nomenclature of PKC isotypes. |
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