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H-2330 HA-1077, Dihydrochloride, >99%
[1-(5-Isoquinolinesulfonyl)homopiperazine, Di-HCl Salt]
[Eril] [Fasudil]
| M.W. 364.30 |
C14H17N3
O2S•2HCl |
[103745-39-7] |
M.I. 12: 3980 |
Storage: Store at or below -20 ºC. Solubility:
Soluble in water (>200 mg/ml) or ethanol. Disposal: A
 | Inhibitor of MLCK (Ki = 20 nM) and CAM kinase (Ki
= 1.8 nM). Ca2+ antagonist; has antivasospastic properities.
Asano, T. et al. "Vasodilator actions of HA1077 in vitro and
in vivo putatively mediated by the inhibition of protein kinases."
Br. J. Pharmacol. 98: 1091-1100 (1989). Sasaki, Y. and Sasaki,
Y. "Inhibition of myosin light chain phosphorylation in cultured smooth
muscle cells by HA1077, a new type of vasodilator." Biochem. Biophys.
Res. Commun. 171: 1182-1187 (1990). Seto, M. et al.
"Effects of HA 1077, a protein kinase inhibitor, on myosin phosphorylation
and tension in smooth muscle." Eur. J. Pharmacol. 195:
267-272 (1991). Shibaya, O. et al. Acta Neurochim. 90:
53 (1988). Shirotani, M. et al. "A new type of vasodilator, HA
1077, an isoquinoline derivative, inhibits proliferation of bovine vascular
smooth muscle cells in culture." J. Pharmacol. Exp. Ther. 259:
738-744 (1991). |
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