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GENTAUR
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H-5239 H-89, Dihydrochloride, >99%
[N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline
sulfonamide, Di-HCl Salt]
| M.W. 519.20 |
C20H20BrN3O2S•2HCl
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[127243-85-0] |
Storage: Store desiccated at or below -20 ºC. Solubility:
Soluble in DMSO or ethanol/water. Disposal: A
 | Potent and selective inhibitor of PKA, with an IC50
of about 50 nM. Chijiwa, T. et al. J. Biol. Chem. 265:
5267-5272 (1990). |
| Also inhibits PKG and the µ isotype of PKC (at about 500 nM). In
contrast, most other PKC isotypes are much more weakly inhibited, with IC50's
in the 32 µM range. Johannes, F.-J., Prestle, J., Dieterich, S.,
Oberhagemann, P., Link, G. and Pfizenmaier, K. "Characterization of
activators and inhibitors of protein kinase Cµ." Eur. J. Biochem.
227: 303-307 (1995). |
| Please request Technical Note #24 for additional information. |
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