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GENTAUR
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I-5700 Ionomycin, Free Acid, >99%
This compound is currently out of stock and is anticipated
to be
ready for shipment on the following date: indefinite.
| M.W. 709.02 |
C41H72 O9
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[56092-81-0] |
RTECS: NO0600000 |
Warning: Toxic.
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Disposal: A
 | Antibiotic that acts as a potent and selective calcium ionophore; more
effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH
range with the resulting complex exhibiting intense UV absorption. Liu, C.
M., et. al. "Characterization of ionomycin as a calcium ionophore."
J. Biol. Chem. 253: 5892-5894 (1978). Kauffman R. F., et.
al. "Cation transport and specificity of ionomycin. Comparison with
ionophore A23187 in rat liver mitochondria." J. Biol. Chem. 255:
2735-2739 (1980). |
| Ionomycin induces apoptosis in immature B cell lines, for example, in
Burkitt lymphoma cells, and in cultured embryonic rat cortical neurons.
More mature B cell lines do not undergo apoptosis, but are arrested in the
G1 phase of the cell cycle. Takei, N., et. al. "Ca2+
ionophore-induced apoptosis on cultured embryonic rat cortical neurons."
Brain Res. 652: 65-70 (1994). Aagaard-Tillery, K.M., et. al.
"Differential activation of a calcium-dependent endonuclease in human B
lymphocytes. Role in ionomycin-induced apoptosis." J. Immunol.
155: 3297-3307 (1995). |
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