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I-7424 Ingenol 3,20-Dibenzoate, >97%
| M.W. 556.66 |
C34H36O7
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[59086-90-7] |
SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when
using this compound. Care must be taken to prevent contact through all
routes of exposure.
Storage: Store at or below 4 ºC. Solubility: Soluble in
DMSO or ethanol. Disposal: A
 | Unusually high mouse ear inflammatory activity, even though the
20-hydroxy group is blocked with a benzoate ester; it appears likely that
this high potency is due to metabolic cleavage of the 20-benzoate group,
which releases the much more potent ingenol 3-benzoate. Sorg, B. and Hecker,
E. Z. Naturforsch. 37b: 748-756 (1982). |
| Shows potent antileukemic activity in the P388 mouse assay. Kupchan,
S.M. et al. Science 191: 571-572 (1976). |
| Suggestions that ingenol 3,20-dibenzoate is a selective activator of PKCe
appear to be incorrect. |
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