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GENTAUR
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Fax: + 32 16 50 90 45
info@genprice.com
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• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
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O-3590 Olomoucine, >99%
[6-Benzylamino-2-(2'-hydroxyethylamino)-9-methylpurine]
| M.W. 298.35 |
C15H18N6O
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[101622-51-9] |
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Disposal: A
 | Potent and very selective, competitive inhibitor of the cyclin-dependent
kinases cdc2 (IC50 = 7 µM) and cdk2/cdk5 (IC50
= 3 µM) at the ATP binding site. Inactive against cdk4 and cdk6. Vesely,
J. et al. Eur. J. Biochem. 224: 771-786 (1994). |
| Olomoucine arrests cell growth at both the G1/S and G2/M boundaries.
Abraham, R.T. et al. Biol. Cell 83: 105-120 (1995).
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| A similar compound, Roscovitine, Cat. No. R-1234, is also quite useful
and somewhat more potent than olomoucine for cdc/cdk studies. |
| Please request Technical Note #25 for additional information. |
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