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GENTAUR
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Fax: + 32 16 50 90 45
info@genprice.com
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• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
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• 75005 PARIS • FRANCE
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P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%
[PMA] [TPA] [Cocarcinogen A1]
[12-O-Tetradecanoyl-phorbol 13-Acetate]
| M.W. 616.84 |
C36H56O8
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[16561-29-8]
RTECS: GZ0630000 |
M.I. 12: 7487 |
WARNING: Highly irritant to skin and mucous membranes. SPECIAL
HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this
compound. Care must be taken to prevent contact through all routes of
exposure.
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO or ethanol. Disposal: A
 | This is the most commonly used phorbol ester. It binds to and activates
protein kinase C, causes an extremely wide range of effects in cells and
tissues, and is a very potent mouse skin tumor promoter. Blumberg, P.M.
CRC Crit. Rev. Toxicol. 8: 153-197 and 199-234 (1980). |
| Although PMA is quite toxic, it has shown anti-leukemic and
anti-neutopenic activity in humans. Han, Z.T. et al. Proc. Natl.
Acad. Sci. USA 95: 5357-5361 (1998) and Proc. Natl. Acad.
Sci. USA 95: 5362-5365 (1998). |
| Beginning with our lot #F-151, we now guarantee purity of 99.5% or
greater for this product as measured by HPLC at 254nm. |
| Please request Technical Note #14 for additional information. |
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