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P-4313 PD 98059, >99%
[2'-Amino-3'-methoxyflavone]
| M.W. 267.28 |
C16H13NO3
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[167869-21-8] |
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Appearance: Pale-yellow powder Disposal:
A
 | Potent, selective and cell-permeable inhibitor of MAP kinase kinase
(also known as MAPK/ERK kinase or MEK kinase). Inhibits phosphorylation of
MAP kinase by MAP kinase kinase. PD 98059 does not inhibit MAP kinase
itself. IC50 values for PD 98059-induced effects are
in the 1-20 µM range for many assays; it is somewhat weaker in inhibiting
cell growth in monolayers or agar for some cell lines. Dudley, D.T. et
al. Proc. Natl. Acad. Sci. USA 92: 7686-7689 (1995).
Pang, L. et al. J. Biol. Chem. 270: 13585-13588
(1995). Waters, S.B. et al. J. Biol. Chem. 270:
20883-20886 (1995). Langlois, W.J. et al. J. Biol. Chem.
270: 25320-25323 (1995). Alessi, D.R. et al. J. Biol. Chem.
270: 27489-27494 (1995). |
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