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P-4833 Phorbol 12,13-Dibutyrate, >99%
[PDBu]
| M.W. 504.63 |
C28H40O8
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[37558-16-0] |
RTECS: EK7767000 |
WARNING: Highly irritant to skin and mucous membranes. SPECIAL
HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this
compound. Care must be taken to prevent contact through all routes of
exposure.
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO or ethanol. Disposal: A
 | Widely used PKC activator; less potent than PMA, but also less
hydrophobic, making it easier to wash out of cells in tissue culture. |
| This was the ligand used, in radioactive form, in the discovery of the
phorbol ester receptor. Driedger, P.E. and Blumberg, P.M. Proc. Natl.
Acad. Sci. USA 77: 567-571 (1980). |
| Tritium-labeled PDBu, [3H]PDBu, is available from several
suppliers of radiochemicals. |
| Please request Technical Note #14 for additional information. |
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