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GENTAUR
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P-9600 Paclitaxel, >99.5%
[Taxol] [Baccatin III N-benzyl-b-phenylisoserine
ester]
| M.W. 853.92 |
C47H51NO14 |
[33069-62-4] |
M.I. 12: 7117 |
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO or ethanol. Disposal: A
 | Antitumor and antileukemic agent isolated from the bark of the yew tree,
Taxus brevifolia. Wani, M.C., et al. "Plant antitumor
agents. VI. The isolation and structure of taxol, a novel antileukemic and
antitumor agent from Taxus brevifolia." J. of Amer. Chem. Soc. 93:
2325-2327 (1971). McGuire, W., et al. "Taxol: a unique
antineoplastic agent with significant activity in advanced ovarian
neoplasms." Ann. Int. Med. 111: 273-279 (1989). |
| Binds to β-tubulin and promotes the assembly of microtubules that resist
depolymerization preventing normal cell division. Rowinsky, E.K., et al.
"Taxol: a novel investigational antimicrotubule agent." Int. J. Cancer
82: 1247-1259 (1990). Parekh, H. and Simpkins, H. "The transport
and binding of taxol." Gen. Pharmacol. 29: 167-172 (1997).
Jordan, A., et al. "Tubulin as a target for anticancer drugs:
agents which interact with the mitotic spindle investigational
antimicrotubule agent." Med. Res. Rev. 18: 259-296 (1998). |
| Induces apoptosis through a JNK-dependent pathway in the early phase
followed by a JNK-independent pathway that results in Bcl-2 phosporylation.
Wang, T.H., et al. "Microtubule dysfunction induced by paclitaxel
initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and
-independent pathways in overian cancer cells." J. Biol. Chem. 274:
8208-8216 (1999). Shtil, A.A., et al. "Differential regulation of
mitogen-activated protein kinases by microtubule-binding agents in human
breast cancer cells." Oncogene 18: 377-384 (1999).
Srivastava, R.K. et al. "Involvement of microtubules in the
regulation of Bcl2 phosphorylation and apoptosis through cyclic
AMP-dependent protein kinase." Mol. Cell. Biol. 18: 3509-3517
(1998). Torres, K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell
death are concentration dependent." Cancer Res. 58: 3620-3626
(1998). |
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