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S-1700 SB 202190, >99%
[4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole]
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Disposal: A
 | SB202190, a pyridinyl imidazole, inhibits p38 kinase activity in vivo
through competition with ATP. Young, P.R., et al. "Pyridinyl
Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP
Site." J. Biol. Chem. 272: 12116-12121 (1997). |
| Induces apoptosis through activation of cysteine protease (CPP32)-like
caspases . Nemoto, S., et al. "Induction of apoptosis by SB202190
through inhibition of p38beta mitogen-activated protein kinase." J Biol
Chem. 273: 16415-16420 (1998). |
| Blocks both lipopolysaccharide (LPS)-induced gene expression and nitric
oxide (NO)-induced stabilization of interleukin (IL)-8 mRNA in monocytes.
Manthey, C.L., et al. "SB202190, a selective inhibitor of p38
mitogen-activated protein kinase, is a powerful regulator of LPS-induced
mRNAs in monocytes." J Leukoc Biol. 64: 409-417 (1998). Ma,
P., et al. "Nitric oxide post-transcriptionally up-regulates
LPS-induced IL-8 expression through p38 MAPK activation." J Leukoc Biol.
76: 278-287 (2004). |
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