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S-3400 SB 203580, >99%
[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazole]
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Appearance: white to off-white solid.
Disposal: A
 | Important, highly specific new inhibitor of the kinase known variously
as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase.
Gallagher, T. F. et al. "2,4,5-Triarylimidazole inhibitors of Il-1
biosynthesis." Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995).
Cuenda, A. et al. "SB203580 is a specific inhibitor of MAP kinase
homologue which is stimulated by cellular stresses and interleukin-1."
FEBS Lett.. 364: 229-233 (1995). Hazzalin, C.A. et al.
"Effects of the inhibition of p38/RK MAP kinase on induction of five fos
and jun genes by diverse stimuli." Oncogene 15:
2321-2331 (1997). |
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