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GENTAUR
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S-8507 Sodium Orthovanadate, UltraPure Research
Grade, >99.9% (metals basis)
[Vanadate] [Pervanadate] [Sodium
Vanadate] [Decavanadate]
| M.W. 183.91 |
Na3VO4 |
[13721-39-6] |
RTECS: YW1120000 |
Storage: Store at room temperature. Disposal: M
 | Our product is >99.9% pure — ultrahigh purity for biological research;
see specifications below. Compare to a major competitor offering only 90%
purity! |
| Potent inhibitor of alkaline phosphatase. Seargeant, L.E. and Stinson,
R.A. Biochem. J. 181: 247-250 (1979). |
| Inhibits protein tyrosine phosphatase. Swarup, G. et al.
Biochem. Biophys. Res. Comm. 107: 1104-1109 (1982). |
| Regarding "decavandate": across the pH range of 1-13, aqueous solutions
of [VO4]3- ion involve a dozen or more ionic species,
both monomeric and oligomeric, whose abundances depend strongly on pH and
[VO4]3- concentration. At pH 3.75 a stable complex
can be prepared (using methods in Fohr et al. below) which contains
ten vanadium atoms and hence is a "decavanadate" ion. When diluted to pH
7.2, the decavandate species has a half-life of about 2 hours. Fohr et
al. also provide directions for making control solutions of mixed
vanadate complexes in which decavandate is absent and monomeric
orthovanadate is present. Fohr, K.J. et al. Biochem. J.
262: 83-89 (1989). Cotton, F.A. and Wilkinson, G. Advanced
Inorganic Chemisty, 3rd Edition, pp. 820-823. Interscience, New York
(1972). |
| Decavandate inhibits inositol 1,4,5-trisphosphate- (IP3-)induced
calcium release from permeabilized endocrine cells with an IC50
of 5 µM (see Fohr et al. above). |
| Decavanadate inhibits the binding of [3H]IP3 to
its receptor in cerebellar and adrenal cortical membranes with potencies of
2.6 µM and 2.2 µM, respectively, an effect not shared by orthovanadate at
concentrations up to 100 µM. The specificity of decavanadate is low,
however, because it also competes with inositol-1,3,4,5-tetrakisphosphate
(IP4) for IP4 receptors, inhibits IP4-stimulated
calcium release and IP4 5-phosphatase, and inhibits IP3
5-phosphatase and IP3 3-kinase, all at 0.6-50 µM. Strupish, J.
et al. Biochem. J. 277: 294 (1991). |
| Typical Analysis:
|
Vanadium....................................27.43% |
|
Chromium...................................<0.0002% |
|
Iron.............................................<0.004% |
|
Nickel.........................................<0.002% |
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Zinc............................................<0.002% |
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