|
GENTAUR
Tel: +32 16 58 90 45
Fax: + 32 16 50 90 45
info@genprice.com
Av. de l'Armée 68
• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
Tel: 01 43 25 01 50
9, Rue Lagrange
• 75005 PARIS • FRANCE
| |
S-8985 Sodium Fluoride, UltraPure Research Grade,
>99.9%
| M.W. 41.99 |
NaF |
[7681-49-4]
RTECS: WB0350000 |
M.I. 12: 8762 |
CAUTION: Toxic.
Storage: Store desiccated at room temperature or below.
Solubility: Soluble in water. Disposal: F
 | Our product is >99.99% pure — utrahigh purity for biological research;
see specifications below. Compare to competitors offering 100-fold lower
purity. |
| Fluoride ion induces a variety of effects thought to be initiated by
stimulation of both stimulatory and inhibitory guanine nucleotide binding
proteins ("G-proteins") followed by effects of those G-protein on adenylyl
cyclase and other targets. The action of F- is thought to
involve the species [AlF4]-, formed by reaction of F-
with aluminum ions leached from glass vessels and/or otherwise present as
contaminants in virtually all aqueous media and buffers used in routine
biological research. Many studies report an increase in the effects of NaF,
or in its potency, when it is supplemented with aluminum salts. Typically
aluminum chloride at about 10 µM is used in conjuction with 1-20 mM NaF.
Occasional studies report no increase in NaF effects when Al3+ is
added, presumably due to an already-saturating level of aluminum ions in the
experimental media. Sternweis, P.C. and Gilman, A.G. Proc. Natl. Acad.
Sci. USA 79: 4888-4891 (1982). Smigel, M. et al.
Advances in Cyclic Nucleotide and Protein Phosphorylation Research
(Greengard, P. et al. eds.) pp. 1-8, Raven Press, New York (1984).
Katada, T. et al. J. Biol. Chem. 259: 3578-3585
(1984). Strnad, C.F. et al. FEBS Letters 206: 20-24
(1986); see also the corresponding erratum, FEBS Letters 221:
247 (1987). O'Shea, J.J. et al. J. Immunol. 139:
3463-3469 (1987). |
| Typical Analysis:
|
Acidity...........................................<0.03 meq/g |
|
Basicity.........................................<0.001 meq/g |
|
Calcium.........................................<0.0004% |
|
Chloride.........................................<0.0004% |
|
Lead..............................................<0.0003% |
|
Lithium..........................................<0.0005% |
|
Magnesium....................................<0.0002% |
|
Manganese....................................<0.00005% |
|
Potassium.....................................<0.0190% |
|
Silicon...........................................<0.0320% |
|
|
