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GENTAUR
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S-9300 Staurosporine, >99%
[Antibiotic AM-2282]
| M.W. 466.20 |
C28H26 N4O3
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[62996-74-1] |
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO or ethanol; insoluble in water. Disposal: A
 | Staurosporine is a potent inhibitor of many, many kinases including
protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and
protein kinase G (IC50 = 8.5 nM). Matsumoto, H., et. al.
"Staurosporine, a protein kinase C inhibitor, interferes with proliferation
of arterial smooth muscle cells." Biochem. Biophys. Res. Commun.
158: 105-109 (1989). Tamaoki, T., et. al. "Staurosporine, a
potent inhibitor of phospholipid/Ca++dependent protein kinase." Biochem.
Biophys. Res. Commun. 135: 397-402 (1986). |
| Staurosporine induces apoptosis in human neuroblastoma cell lines and
chick embryonic neurons. Boix, J., et. al. "Characterization of the
cell death process induced by staurosporine in human neuroblastoma cell
lines." Neuropharmacology 36: 811-821 (1997). Wiesner, D.A.
and Dawson, G., "Staurosporine induces programmed cell death in embryonic
neurons and activation of the ceramide pathway." J. Neurochem. 66:
1418-1425 (1996). |
| Please request Technical Note #24 for additional information |
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