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T-2710 Tyrphostin SU 1498, >99%
[(E)-N-(3"-Phenylpropyl)- a-cyano-3',5'-diisopropyl-4'-hydroxycinnamamide]
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Appearance: Pale yellow solid. Disposal:
A
 | Potent and selective inhibitor of the VEGF receptor kinase, Flk-1 (IC50
= 700 nM). Very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2
kinase. Strawn, L.M. et al. "Flk-1 as a target for tumor growth
inhibition." Cancer Res. 56: 3540-3545 (1996). |
| Vascular endothelial growth factor (VEGF) has been shown to play a role
in angiogenesis. SU 1498 inhibits vascular permeability as well as
angiogenesis in cellular and animal studies. |
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