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GENTAUR
Tel: +32 16 58 90 45
Fax: + 32 16 50 90 45
info@genprice.com
Av. de l'Armée 68
• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
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• 75005 PARIS • FRANCE
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T-3250 Thapsigargin, >99%
| M.W. 650.76 |
C34H50O12
|
[67526-95-8] |
WARNING: Highly irritant to skin and mucous membranes. SPECIAL
HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this
compound. Care must be taken to prevent contact through all routes of
exposure.
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO or ethanol. Disposal: A
 | Potent, cell permeable IP3-independent intracellular calcium
releaser. Takemura, H. et al. J. Biol. Chem. 264:
12266-12271 (1989). |
| Inhibits microsomal Ca2+-ATPase. Thastrup, O. et al.
Agents Actions 27: 17-23 (1989). |
| Rat mast cell histamine secretagogue. Patkar, S.A. Acta Pharm.
Suecica 15: 133-140 (1978). Agents Actions 9:
53-57 (1979). |
| Mouse skin tumor promoter with potency somewhat weaker than teleocidin
or PMA, but does not bind to protein kinase C or induce ornithine
decarboxylase activity. Hakii, H. et al. J. Cancer Res. Clin.
Oncol. 111: 177-181 (1986). |
| Stimulates arachidonic acid metabolism in macrophages. Ohuchi, K. et
al. J. Cancer Res. Clin. Oncol. 113: 319-324 (1987).
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| Please request Technical Note #15 for additional information. |
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