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GENTAUR
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T-7310 Tyrphostin AG 1478, >99%
[AG 1478] [4-(3'-Chloroanilino)-6,7-dimethoxy-quinazoline]
| M.W. 315.76 |
C16H14ClN3
O2 |
[175178-82-2] |
Storage: Store at or below -20 ºC. Solubility: Very
soluble in DMSO, to more than 50 mg/ml. Appearance: White
solid. Disposal: A
 | Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50
= 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50
> 100 µM). Osherov, N. and Levitsky, A. Eur. J. Biochem. 225:
1047-1053 (1994). Levitsky, A. and Gazit, A. Science 267:
1782-1788 (1995). |
| Reversibly inhibits (IC50 = 9.8 µM) the rat brain
Kv1.5 potassium channel in vitro in a
non-protein-tyrosine-kinase-mediated manner. Choi, B.K. et al.
Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002). |
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