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GENTAUR
Tel: +32 16 58 90 45
Fax: + 32 16 50 90 45
info@genprice.com
Av. de l'Armée 68
• B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE
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• 75005 PARIS • FRANCE
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U-6770 U0126, >99%
[1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene]
Storage: Store at or below -20 ºC. Solubility:
Soluble in DMSO. Appearance: White solid. Disposal: A
 | Selective inhibitor of the mitogen-activated protein kinase kinases,
MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at
most, a weak inhbitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6,
Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in
cell-based reporter assays. Favata, M.F. et al. "Identfication of a
novel inhibitor of mitogen-activated protein kinase kinase." J. Biol.
Chem. 273: 18623-18632 (1998). DeSilva, D.R. et al.
"Inhibition of mitogen-activated protein kinase kinase blocks T cell
proliferation but does not induce or prevent anergy." J. Immuol.
160: 4175-4181 (1998). Scherle, P.A. et al. "Inhibition of MAP
kinase kinase prevents cytokine and prostaglandin E2 production in
lipopolysaccharide-stimulated monocytes." J. Immuol. 161:
5681-5686 (1998). |
| Our U0126 is highly purified. In crystalline form and in aprotic
solvents it is a single chemical entity. However, it appears that, in
solution in protic solvents, U0126 exists as a mixture of isomers. This
phenomenon does not affect overall biological activity. Note that DMSO
normally contains water so that it behaves, in this case, as a protic
solvent. (PKC Pharmaceuticals, Inc., unpublished results.) |
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