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GENTAUR Tel: +32 16 58 90 45 Fax: + 32 16 50 90 45 Av. de l'Armée 68 • B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE Tel: 01 43 25 01 50 9, Rue Lagrange • 75005 PARIS • FRANCE |
Anti-LPL Monoclonal AntibodyMouse Monoclonal (IgG1)
Clone:
LPL.A4 Immunogen: Human LPL whole protein Specificity: Recognize specifically LPL from human and bovine. Formulation: 1mg/ml in PBS, pH 7.4 with 0.05% sodium azide. Frozen liquid. Storage/Stability: Stable for one year at –20ºC from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stable at 4ºC for 3 months. Application: Western blot (1:1000) and ELISA (1:2000~5000) in lipid metabolic research. Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation. |
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