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GENTAUR Tel: +32 16 58 90 45 Fax: + 32 16 50 90 45 Av. de l'Armée 68 • B-1040 BRUSSELS • BELGIUM
GENTAUR FRANCE Tel: 01 43 25 01 50 9, Rue Lagrange • 75005 PARIS • FRANCE |
Anti-SRY Monoclonal Antibody Mouse Monoclonal IgG
Catalog #: G47-1000 Quantity: 100μg Clone: SRY.G12 Immunogen: SRY-GST fusion protein. Specificity: Recognize mouse SRY protein, others not tested. Formulation: 1mg/ml in PBS, pH 7.4 with 0.05% sodium azide. Frozen liquid. Storage/Stability: Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. Aliquot will be stale at 4°C for 3 months. Application: Western blot (1:1000) and ELISA (1:2000~5000). The Sex-Determining Region (SRY) is a gene that encodes a transcription factor that is a member of the high mobility group HMG-box family of DNA binding proteins.The gene is located on the short arm of the Y chromosome and has a gene map locus - Yp11.3.Common synonyms of the gene name are Testis Determining Factor (TDF) and Testis Determining Factor on Y (TDY). The main function of the SRY protein is to initiate male sex determination as a transcriptional activator, which regulates a genetic switch in male development. The SRY HMG box recognizes DNA by partial intercalation in the minor groove. The SRY protein then binds to the DNA and distorts its shape (SRY protein in action). In doing so, it regulates genes that control the development of the testes. |
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